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Current Molecular Medicine

Eiditor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Research Article

Association of IL33 and IL1RAP Polymorphisms With Acute Anterior Uveitis

Author(s): X.-F. Huang, W. Chi, D. Lin, M.-L. Dai, Y.-L. Wang, Y.-M. Yang, Z.-B. Jin* and Y. Wang*

Volume 17 , Issue 7 , 2017

Page: [471 - 477] Pages: 7

DOI: 10.2174/1566524018666180207154938

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Abstract

Background: AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system.

Objective: In the present study, we investigated the association of IL33 and IL1RAP genes with AAU.

Method: A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology.

Results: Our findings demonstrated that IL1RAP-rs3773978 significantly associated with AAU and could serve as a genetic risk marker in Chinese AAU patients. A significantly increased frequency of the A allele and AA homozygosity of IL1RAP-rs3773978 was observed in AAU patients compared with that in controls (p=0.001, pc=0.01, OR=1.282, 95% CI 1.106 to 1.487; p=0.0003, pc=0.003, OR=1.647, 95% CI 1.255 to 2.163, respectively). Further stratification analyses showed that the genetic correlation may differ depending on HLA-B27 status, AS (ankylosing spondylitis) status, attack times and laterality status.

Conclusion: Our findings provide new insights that enhance the current knowledge of uveitis genetics by demonstrating the specific functional roles of IL1RAP and other IL-1 family genes in uveitis.

Keywords: IL33, IL1RAP, acute anterior uveitis, association analysis, innate immune system, vision loss.


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