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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Rheumatic Heart Disease: Pathogenesis and Vaccine

Author(s): L. Guilherme*, S. Freschi de Barros, K.F. Kohler, S.R. Santos, F. Morais Ferreira, W.R. Silva, R. Alencar, E. Postol and J. Kalil

Volume 19 , Issue 9 , 2018

Page: [900 - 908] Pages: 9

DOI: 10.2174/1389203718666170725115855

Price: $58


Rheumatic fever (RF) and rheumatic heart disease (RHD) follow untreated S. pyogenes throat infections in children who present susceptible genes that favor the development of autoimmune reactions. In this review, we focus on the genes that confer susceptibility and on the autoimmune reactions that occur due to molecular mimicry between human-tissue proteins and streptococcal M protein. Polyarthritis is the initial manifestation, which can evolve to carditis and severe valve damage; these culminate in rheumatic heart disease (RHD) or Sydenham’s chorea, which affects the central nervous system. A perspective on vaccine development to prevent the disease is also discussed.

Keywords: Rheumatic fever, rheumatic heart disease, M protein, genes, cytokines, T and B lymphocytes, heart-tissue proteins, anti-S. pyogenes vaccine.

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