Objective: To evaluate the correlation between smoking and types of coronary atherosclerotic plaques using Double-Source Computed Tomography (DSCT) angiography.
Methods: Patients who underwent DSCT Coronary Angiography (DSCTCA) at our hospital between April 2012 and April 2013 were enrolled and divided into a smoking group and a nonsmoking group according to their response to a questionnaire of smoking. Patients with a familial genetic history of coronary or concomitant diabetes mellitus, hypertension, or hyperlipidemia were considered and divided into two groups according to their smoking history, as 200 smokers and 200 non-smokers were selected for the study. The incidence rates, distribution characteristics, and types of plaque were identified and compared between the two groups.
Results: The incidences of mixed plaques (44.7% vs. 21.9%) and non-calcified plaques (38.7% vs. 67.9%) were significantly different between the smoking group and the non-smoking group (both P <0.05). When the data were adjusted for age, sex, and weight index, smoking was an independent risk factor for formation of mixed plaques. The smoking group was subdivided according to the Smoking Index (SI) and a comparison showed that the incidence of mixed plaques increased with increasing SI.
Conclusion: DSCTCA can accurately evaluate differences in coronary atherosclerotic plaques between smokers and non-smokers. Smokers are more likely to develop mixed plaques and are at higher risk of cardiovascular events, and the plaques are distributed more widely.
Keywords: Tomograph, smoking, coronary artery disease, cigarette index, plaques, DSCTCA.
Diabetic Heart and the Cardiovascular Surgeon
Cardiovascular & Hematological Disorders-Drug Targets Mechanistic Insights Into Diabetes Mellitus and Oxidative Stress
Current Medicinal Chemistry Protein-Tyrosine Phosphatase 1B (PTP1B): A Novel Therapeutic Target for Type 2 Diabetes Mellitus, Obesity and Related States of Insulin Resistance
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Endless Pursuit: Evolution of Insulin Administration
Current Pharmaceutical Biotechnology Docking Study of Novel Pyrrolidine Derivatives as Potential Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors
Letters in Drug Design & Discovery Cardiac Mitochondrial Alterations Observed in Hyperglycaemic Rats - What Can We Learn From Cell Biology?
Current Diabetes Reviews Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer
Current Pharmaceutical Design Update on Pharmacologic Approaches to Prevent Thromboembolism in Atrial Fibrillation: Are Thrombin and Factor Xa Inhibitors the Ultimate Answer?
Current Vascular Pharmacology Extracellular Vesicles and Insulin Resistance: A Potential Interaction in Vascular Dysfunction
Current Vascular Pharmacology New-onset Diabetes Mellitus: Predictive Factors and Impact on the Outcome of Patients Undergoing Liver Transplantation
Current Diabetes Reviews Impact of Diabetes on Vasculature: Focus on Nervous System
Current Diabetes Reviews Genetics in Gestational Diabetes Mellitus: Association with Incidence, Severity, Pregnancy Outcome and Response to Treatment
Current Diabetes Reviews Does Global Gene Expression Analysis in Type 2 Diabetes Provide an Opportunity to Identify Highly Promising Drug Targets?
Endocrine, Metabolic & Immune Disorders - Drug Targets Impact of Diabetes Mellitus on Radiological Presentation of Pulmonary Tuberculosis in Otherwise Non-Immunocompromised Patients: A Systematic Review
Current Medical Imaging An Improved Synthetic Method of Saxagliptin Intermediate 3-Hydroxy-1- acetyladamantane and Its Characterization
Letters in Organic Chemistry Adiponectin and Cardiovascular Disease: Mechanisms and New Therapeutic Approaches
Current Medicinal Chemistry Ezetimibe Therapy for Dyslipidemia: An Update
Current Pharmaceutical Design Investigating Key Genes in Type 2 Diabetes Mellitus via Combining mAP-KL and Mutual Information Network
Current Bioinformatics Mild Carbohydrate Intolerance in Pregnancy
Current Diabetes Reviews Modulation of Nitric Oxide Pathway by Multiligands/RAGE Axis: A Crossing Point on the Road to Microvascular Complication in Diabetes
Current Enzyme Inhibition