Background: Consumption of nuts particularly walnuts has been widely recommended for lowering the risk of coronary heart disease; however, very few studies have evaluated the potential unfavourable effects that Walnut seeds might have in vivo.
Objective: To investigate the long-term effects of Juglans regia seed supplementation in specially formulated feed when fed to developed mice model.
Method: C57BL/6J male mice were divided into four groups, labelled, C (control), T (High Fat Simple Carbohydrate- HFSC), Cw (control + walnut) and Tw (HFSC+ walnut) based on diet. Four mice from each group were sacrificed at the end of the first and fifth month respectively. Blood samples were collected every month. Bleeding time, blood platelet number and morphology were studied. Histopathological analysis of heart and aorta were also performed.
Results: Groups Cw and Tw showed a significant increase in platelet count; however, platelet activation was not detected. There was a trend to an increase in bleeding time in group Cw. Expanded lumen diameter of the aorta was observed in Cw and Tw mice initially, however, it was found to constrict by the end of the study. A large amount of peripheral fat deposition in the aortas of Cw and Tw was observed, which increased through the course of the experiment.
Conclusion: Kashmiri walnut seed supplementation was found to reduce the signs in shape change of platelets as well as increase platelet number with a trend to an increased bleeding time. This observation could be of medical interest. Histopathological analysis of heart and aorta showed lipid sequestration which merits further investigations.
Keywords: Kashmiri walnut seed, platelet number, platelet activation, histopathology, heart, aorta.
The Role of PPARs in Obesity and other Insulin Resistance Associated Disorders
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila
Current Genomics Endothelial Dysfunction, Oxidative Stress and Inflammation in Atherosclerosis: Beneficial Effects of Statins
Current Medicinal Chemistry Blood Pressure and Childhood Obesity
Current Hypertension Reviews Dyslipidemia Treatment and Cardiovascular Disease in the Renal Patient
Current Pharmaceutical Design New Insights into the Mechanisms Underlying Vascular and Cardiac Effects of Urocortin
Current Vascular Pharmacology Left Ventricular Hypertrophy: A Shift in Paradigm
Current Medicinal Chemistry Statins and Left Ventricular Function
Current Pharmaceutical Design The Role of Endogenous H2S in Cardiovascular Physiology
Current Pharmaceutical Biotechnology Natural Phenolic Compounds as Cardiovascular Therapeutics: Potential Role of their Antiinflammatory Effects
Current Vascular Pharmacology A Review of Patents on Implantable Heart-Compression/Assist Devices and Systems
Recent Patents on Biomedical Engineering (Discontinued) Animal Models of Diabetes Mellitus: Relevance to Vascular Complications
Current Pharmaceutical Design HDL Elevators and Mimetics - Emerging Therapies for Atherosclerosis
Cardiovascular & Hematological Agents in Medicinal Chemistry The Role of EC-IC Bypass in Critical Cerebral Hemodynamics of Different Origin
Current Hypertension Reviews Oxidative Stress on Progenitor and Stem Cells in Cardiovascular Diseases
Current Pharmaceutical Biotechnology Hypertension and Aortic Stenosis: A Review
Current Hypertension Reviews Vascular Endothelial Function Change in Elderly Chinese Patients with Obstructive Sleep Apnea and its Association with Coronary Heart Disease
Vascular Disease Prevention Combinatorial Library Synthesis of Antioxidant Compounds
Combinatorial Chemistry & High Throughput Screening Cardiovascular Remodeling Induced by Passive Smoking
Inflammation & Allergy - Drug Targets (Discontinued) Glibenclamide Action on Myocardial Function and Arrhythmia Incidence in the Healthy and Diabetic Heart
Cardiovascular & Hematological Agents in Medicinal Chemistry