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Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

DNA Methylation: An Epigenetic Insight into Type 2 Diabetes Mellitus

Author(s): Fahmida Alam, Md. Asiful Islam, Siew Hua Gan, Mafauzy Mohamed and Teguh Haryo Sasongko

Volume 22 , Issue 28 , 2016

Page: [4398 - 4419] Pages: 22

DOI: 10.2174/1381612822666160527111152

Price: $58

Abstract

DNA methylation, a major regulator of epigenetic modifications has been shown to alter the expression of genes that are involved in aspects of glucose metabolism such as glucose intolerance, insulin resistance, β -cell dysfunction and other conditions, and it ultimately leads to the pathogenesis of type 2 diabetes mellitus (T2DM). Current evidences indicate an association of DNA methylation with T2DM. This review provides an overview of how various factors play crucial roles in T2DM pathogenesis and how DNA methylation interacts with these factors. Additionally, an update on current techniques of DNA methylation analysis with their pros and cons is provided as a basis for the adoption of suitable techniques in future DNA methylation research towards better management of T2DM. To elucidate the mechanistic relationship between vital environmental factors and the development of T2DM, a better understanding of the changes in gene expression associated with DNA methylation at the molecular level is still needed.

Keywords: DNA methylation, T2DM, epigenetics, risk factors, methods, gene.


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