There is a paucity of research and a lack of necessary guidance for proper characterization of pulmonary hypertension presenting in patients with connective tissue disease and interstitial lung disease, specifically related to differentiating between WHO group 1 pulmonary arterial hypertension and WHO group 3 pulmonary hypertension due to lung disease and/or hypoxia. Without a mechanism for proper differentiation of the type of pulmonary hypertension that exists, appropriate management of this subset of individuals is particularly challenging. This review presents the pertinent research that exist regarding the intricacies of this disease state with the goal of providing improved guidance as to who may benefit from screening, diagnosis, treatment in a facility with expertise in the field, and referral for lung transplant.
Keywords: Pulmonary hypertension, pulmonary arterial hypertension, interstitial lung disease, connective tissue disease, parenchymal lung disease, lung transplant.
Hypertension in the Neonatal Period: An Update
Current Hypertension Reviews Clinical Significance of the Sympathetic Nervous System in the Development and Progression of Pulmonary Arterial Hypertension
Current Neurovascular Research Heme Oxygenase-1: A Potential Antihypertensive Target?
Current Hypertension Reviews Radiological Diagnosis of Renal Thrombosis in Children
Current Pediatric Reviews Mechanisms of Endothelial Dysfunction: Clinical Significance and Preventive Non-Pharmacological Therapeutic Strategies
Current Pharmaceutical Design Adipose Tissue as a Regulator of Energy Balance
Current Drug Targets Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity
Current Hypertension Reviews Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials
Current Angiogenesis (Discontinued) Cardiovascular Disease in Patients with Diabetic Nephropathy
Current Molecular Medicine Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Clinical Approach)
Current Hypertension Reviews Left Ventricular Hypertrophy and Angiotensin II Receptor Blocking Agents
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Pulmonary Arterial Hypertension in Connective Tissue Diseases
Current Respiratory Medicine Reviews Current Updates in the Medical Management of Obesity
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Under Re-organization) Genomics and Pharmacogenomics of Salt-sensitive Hypertension
Current Hypertension Reviews Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling
Current Medicinal Chemistry Pleiotropic Effects of ARB in Vascular Metabolism - Focusing on Atherosclerosis-Based Cardiovascular Disease
Current Vascular Pharmacology Soluble RAGE-Modulating Drugs: State-of-the-Art and Future Perspectives for Targeting Vascular Inflammation
Current Vascular Pharmacology Left Ventricular Hypertrophy in ADPKD: Changing Demographics
Current Hypertension Reviews Design, Synthesis, and Structure-Activity Relationship Study of Peroxisome Proliferator-Activated Receptor (PPAR) δ-Selective Ligands
Current Medicinal Chemistry Comparative Study of Nutritional and Phytochemical Attributes of Andrographis paniculata, Bryophyllum pinnatum and Clitoria ternatea for Nutraceutical Applications
Current Nutrition & Food Science