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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress

Author(s): German Barriga-Gonzalez, Claudio Olea-Azar, Maria C. Zuniga-Lopez, Christian Folch-Cano, Benjamin Aguilera-Venegas, Williams Porcal, Mercedes Gonzalez and Hugo Cerecetto

Volume 15 , Issue 5 , 2015

Page: [484 - 495] Pages: 12

DOI: 10.2174/1568026615666150206155108

Price: $58


Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In this review, the importance of spin trapping technique in the study of diseases such as cancer, diabetes, hypertension and parasitic diseases is discussed. In addition, advances in the use of this technique as therapeutic agents and other interesting applications as the immuno-spin trapping technique are reviewed.

Keywords: DMPO, EPR, ESR, Human diseases, Immuno-spin trapping, Oxidative stress, PBN, Spin traps.

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