Background: Nocturnal blood pressure (NBP) abnormalities are often encountered in obstructive sleep apnea (OSA) patients. Both phenomena are associated with increased cardiovascular morbidity and mortality in general hypertensives. The aim of the study was to determine the prevalence of target organ damage (TOD) in different nighttime blood pressure patterns of newly diagnosed OSA patients with early hypertension.
Materials and Methods: Seventy-four patients participated in the study. OSA was verified by a polysomnography. All patients had controlled hypertension. 24-hour BP monitoring divided participants into: 39 (NH) - nocturnal hypertensives; 18 NND - nocturnal normotensive dippers, (NBP fall>10%, NBP<120/70mmHg); 17 (NNN) - nocturnal normotensive non-dippers (NBP fall<10%, NBP<120/70mmHg). Anthropological glucometabolic and sleep study characteristics were collected. Cardiac damage (left ventricular mass index - LVMI, relative wall thickness - RWT) was assessed by a standard echocardiography; renal damage by microalbuminuria and vascular damage by ultrasonography of the carotid vessels.
Results: Left ventricular hypertrophy (LVH) was met in 33% of the dippers, 64.7% of NNN and in 62.6% of NH. LVMI in non-dippers was higher when compared to dippers (127.71± 8.71 vs 109.1± 4.9g/m2, p=0.03) and nearly identical to those in patients with NH (127.71± 8.71 vs 124.18 ± 5.92g/m2, p=0.42). Microalbuminuria was present in 3% and 6% of dippers/non-dippers and in 51% of NH. IMT and RWT were within the same range in the three groups. Multivariate regression analysis showed that: LVMI correlated positively to age and sleep time at SaO2<90%; RWT correlated positively to BMI, age and AHI. IMT and microalbuminuria correlated to none of the parameters.
Conclusion: In newly diagnosed OSA patients with early hypertension (duration <3 years) TOD was detected mostly at cardiac level. It was presented by an increased LVMI, that was associated with the age and the sleep time at SaO2<90%.
Keywords: Cardiac damage, hypoxia, sleep disordered breathing.
Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes
Current Diabetes Reviews A New Antihypertensive Agent that Antagonizes the Prohypertensive Effect of Endogenous Ouabain and Adducin
Cardiovascular & Hematological Agents in Medicinal Chemistry Use of Double-source Computed Tomography for Evaluation of the Relationship Between Smoking and Coronary Plaques
Current Medical Imaging Reducing the Risk of Type 2 Diabetes - Early Identification of High-Risk Individuals and Treatment with Acarbose
Current Diabetes Reviews Combinations of Renin-Angiotensin-Aldosterone System Antagonists:True Advantages?
Current Pharmaceutical Design Hypertension and Diabetes: Emphasis on the Renin-Angiotensin System in Atherosclerosis
Current Hypertension Reviews Adherence to Mediterranean Diet Offers an Additive Protection Over the Use of Statin Therapy: Results from the ATTICA Study (2002-2012)
Current Vascular Pharmacology The 1,4-Dihydropyridine Nucleus: A Pharmacophoric Template Part 1. Actions at Ion Channels
Mini-Reviews in Medicinal Chemistry Genes, Environment, Intermediate Phenotypes, and the Pathogenesis of Diabetic Nephropathy
Current Pharmacogenomics Vascular Remodelling in Well-controlled Hypertensive Patients: The Challenge of Residual Risk Management
Current Pharmaceutical Design C-Reactive Protein and Hypertension: Is there A Causal Relationship?
Current Pharmaceutical Design Plasma Glucose Concentrations and Cardiac Hypertrophy in Essential Hypertension
Current Hypertension Reviews Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Current Pharmaceutical Design Non-dipping Status in Arterial Hypertension: An Overview
Current Vascular Pharmacology Cardiovascular Effects of Current and Future Anti-Obesity Drugs
Current Vascular Pharmacology Cell Therapy for Respiratory Diseases: Optimizing Cell Delivery Strategies
Current Respiratory Medicine Reviews Maternal Nutrient Restriction is not Equivalent to Maternal Biological Stress
Current Drug Targets Determinants of Perceived Severity of Hypertension and Drug-Compliance in Hypertensive Patients
Cardiovascular & Hematological Disorders-Drug Targets The Hellp Syndrome: A Review
Current Women`s Health Reviews Maternal Nutrition and Predisposition to Later Kidney Disease
Current Drug Targets