Gold salts have been introduced as therapeutic agents in the late 19th century. The three gold salts approved for medical therapy auranofin, aurothiomalate, and aurothioglucose were shown to induce anti-inflammatory and immunosuppressive states via a myriad of mechanisms and used to be a mainstay of therapy for rheumatoid arthritis as well as other rheumatic and collagen vascular diseases before being supplanted by other less toxic agents. The research into the role of gold compounds in therapy of pulmonary disease have focused on asthma and demonstrated a significant anti-inflammatory effect as well as a mild steroid-sparing effect mainly in Japanese patients. These effects were offset by a wide array of adverse reactions, notably dermatological, hematological and renal effects. The main pulmonic adverse effect associated with gold therapy is interstitial pneumonitis which can present with an acute, subacute and chronic course. The role of gold salts in the therapeutic arsenal of COPD and interstitial lung diseases is less established. Recently published studies have investigated the role of aurothiomalate as an inhibitor of non-small cell lung cancer oncogene PKC iota.
Keywords: Adverse effects, asthma, gold, interstitial lung disease.
Metformin one in a Million Efficient Medicines for Rheumatoid Arthritis Complications: Inflammation, Osteoblastogenesis, Cardiovascular Disease, Malignancies
Current Rheumatology Reviews Chemometrics-assisted Spectrofluorimetric Determination of Two Co-administered Drugs of Major Interaction, Methotrexate and Aspirin, in Human Urine Following Acid-induced Hydrolysis
Combinatorial Chemistry & High Throughput Screening Parasites in Rheumatoid Arthritis: Imminent Threat or Protective Effect?
Current Rheumatology Reviews Periodontal Diseases and Rheumatoid Arthritis: A Coincident Model for Therapeutic Intervention?
Current Drug Metabolism Soluble Adhesion Molecules in the Pathogenesis of Rheumatoid Arthritis
Current Pharmaceutical Design Mimicking Self-Antigens with Synthetic Peptides in Systemic Autoimmune Rheumatic Diseases
Current Clinical Pharmacology CC Chemokine Receptor Small Molecule Antagonists in the Treatment of Rheumatoid Arthritis and Other Diseases: A Current View
Current Topics in Medicinal Chemistry Dietary Approaches and Alternative Therapies for Rheumatoid Arthritis
Current Nutrition & Food Science Anti-inflammatory Activities of Phenoxyphenyl Ureas Mediated by Inhibition of p38 Kinase
Current Enzyme Inhibition Persistent Clinical Response of Infliximab Therapy in Patients with Refractory Rheumatoid Arthritis, over a 3-Year Period
Current Clinical Pharmacology The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations
Current Drug Targets The Role of Cartilage Oligomeric Matrix Protein (COMP) in Skeletal Disease
Current Drug Targets Granulocyte Apoptosis and Macrophage Clearance of Apoptotic Cells as Targets for Pharmacological Intervention in Inflammatory Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Osteoclast as a New Target in the Treatment of Rheumatoid Arthritis: A Role for the Bisphosphonates?
Current Rheumatology Reviews Predictive Factors for Disability as Evaluated by the Health Assessment Questionnaire in Rheumatoid Arthritis: A Literature Review
Inflammation & Allergy - Drug Targets (Discontinued) Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents
Medicinal Chemistry Why Should Rheumatologists Consider Vitamin D Supplementation for their Patients?
Current Rheumatology Reviews The Protective Effects of Extra Virgin Olive Oil on Immune-mediated Inflammatory Responses
Endocrine, Metabolic & Immune Disorders - Drug Targets Identification of Expressed miRNAs in Human Rheumatoid Arthritis Using Computational Approach – Discovery of a New miR-7167 from Human
MicroRNA Screening Methods for Antioxidants-A Review
Mini-Reviews in Medicinal Chemistry