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Current Drug Delivery

Eiditor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Mucoadhesive Microspheres Containing Anti-Hypertensive Agent: Formulation and Characterization

Author(s): Ankita Sunilbhai Patel, Pande Saikat and Patel Ronakkumar Pravinbhai

Volume 11 , Issue 3 , 2014

Page: [322 - 331] Pages: 10

DOI: 10.2174/1567201810666140110113225

Price: $58

Abstract

The spherical microspheres consisting of Furosemide loaded sodium alginate and along with HPMC E50 or sodium CMC as mucoadhesive polymers in different ratios were prepared using ionic gelation technique. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. Formulations were subjected to DSC study and SEM analysis. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism.

Keywords: Furosemide, Ionic gelation, Mucoadhesive polymers, Sodium alginate.


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