Generic placeholder image

Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Current Status and Perspectives in Ceramide-Targeting Molecular Medicine

Author(s): Hirofumi Sawai, Naochika Domae and Toshiro Okazaki

Volume 11 , Issue 19 , 2005

Page: [2479 - 2487] Pages: 9

DOI: 10.2174/1381612054367463

Price: $58

Abstract

Ceramide is not only structurally but also functionally a key molecule in diverse kinds of sphingolipids. In the past decade, ceramide has been shown to be of crucial significance in several cell functions including apoptosis, cell growth, senescence, and cell cycle control. Among them, the role of ceramide in apoptosis induction has extensively been studied, and ceramide-targeting molecular medicine for apoptosis-based diseases such as malignant tumors, atherosclerosis and neurodegenerative disorders appears to come out to the clinical field. We here describe the recent advances in research of ceramide-mediated apoptosis signaling. We also show the relation of ceramide level through regulation of ceramide-related enzymes (sphingomyelinase, ceramidase, sphingomyelin synthase and glucosylceramide synthase) with diseases such as cancer, leukemia, bacterial infections, AIDS, Alzheimers disease, atherosclerosis, diabetes mellitus and atopic dermatitis. The strategies to construct the ceramide-targeting medicine for intractable diseases such as cancer and leukemia are discussed.

Keywords: ceramide, sphingomyelin, sphingomyelinase, ceramidase, sphingosine-1-phosphate, glucosylceramide, apoptosis, anticancer drug


Rights & Permissions Print Export Cite as
Related Journals
Related eBooks
Article Metrics
3
Related Articles
© 2020 Bentham Science Publishers