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Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Valproic Acid As Anti-Cancer Drug

Author(s): Martin Michaelis, Hans Wilhelm Doerr and Jindrich Cinatl Jr.

Volume 13 , Issue 33 , 2007

Page: [3378 - 3393] Pages: 16

DOI: 10.2174/138161207782360528

Price: $58

Abstract

The short chain fatty acid valproic acid (VPA, 2-propylpetanoic acid) is approved for the treatment of epilepsia, bipolar disorders and migraine and clinically used for schizophrenia. In 1999, the first clinical anti-cancer trial using VPA was initiated. Currently, VPA is examined in numerous clinical trials for different leukaemias and solid tumour entities. In addition to clinical assessment, the experimental examination of VPA as anti-cancer drug is ongoing and many questions remain unanswered. Although other mechanisms may also contribute to VPA-induced anti-cancer effects, inhibition of histone deacetylases appears to play a central role. This review focuses on recent developments regarding the anti-cancer activity of VPA.

Keywords: Valproic acid, HDAC, differentiation, angiogenesis, combination therapy, clinical studies


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