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CNS & Neurological Disorders - Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Different Factors Influence Recanalisation Rate After Coiling in Ruptured and Unruptured Intracranial Aneurysms

Author(s): Iris Q. Grunwald, Joyce S. Balami, Daniela Weber, Jessica Mutter, Anna L. Kuhn, Christoph Krick, Wolfgang Reith, Panagiotis Papanagiotou and Kaveh Shariat

Volume 12 , Issue 2 , 2013

Page: [228 - 232] Pages: 5

DOI: 10.2174/18715273112119990055

Price: $58

Abstract

Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms.

Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.

Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA).

Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027).

Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.

Keywords: Intracranial, aneurysm, ruptured, unruptured, recanalisation.


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