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Endocrine, Metabolic & Immune Disorders - Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach

Author(s): A. Dei Cas, V. Spigoni, V. Ridolfi and M. Metra

Volume 13 , Issue 1 , 2013

Page: [38 - 50] Pages: 13

DOI: 10.2174/1871530311313010006

Price: $58

Abstract

Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.

Keywords: Chronic heart failure, diabetes mellitus, diabetic cardiomyopathy, molecular mechanisms, structural alteration, therapy.


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