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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Eiditor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation

Author(s): Anne Vincent, Benoit Lattuca, Nolwenn Merlet, Catherine Sportouch-Dukhan and Stephanie Barrere-Lemaire

Volume 12 , Issue 1 , 2013

Page: [47 - 54] Pages: 8

DOI: 10.2174/1871523011312010007

Price: $58

Abstract

Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.

Keywords: Inflammation, myocardial injury, ischemia-reperfusion


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