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Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Insight to the Pathophysiology of Stable Angina Pectoris

Author(s): Dimitris Tousoulis, Emmanuel Androulakis, Anna Kontogeorgou, Nikolaos Papageorgiou, Marietta Charakida, Katerina Siama, George Latsios, Gerasimos Siasos, Anna-Maria Kampoli, Panagiotis Tourikis, Kostas Tsioufis and Christodoulos Stefanadis

Volume 19 , Issue 9 , 2013

Page: [1593 - 1600] Pages: 8

DOI: 10.2174/1381612811319090007

Price: $58

Abstract

Atherosclerosis is a chronic disease which mainly represents an inflammatory response in the vessels. Myocardial ischemia manifested by angina pectoris can be either acute or chronic and usually is a result of imbalance between myocardial oxygen supply and myocardial oxygen demand. Chronic stable angina is chest discomfort attributed to myocardial ischemia without the presence of necrosis and is the most common symptom encountered by emergency room physicians. A growing amount of data has shown that endothelial dysfunction, is now considered an important early event in the development of atherosclerosis, while in the absence of angiographically obstructive coronary artery disease, anginal chest pain is often attributed to microvascular coronary dysfunction. Moreover, atheroma formation and in turn, atherosclerotic plaques seem to affect coronary flow, given that multivessel flow-limiting obstructions are observed in patients with chronic coronary syndrome. Morphological changes of diseased arteries related to significant atherosclerosis, such as vascular remodeling may also result in stable angina or claudication. However, several issues with respect to the comprehension of the pathophysiology of the chronic coronary syndrome have not been fully elucidated.

Keywords: Stable angina, atherosclerosis, pathophysiology, myocardial ischemia, chronic disease, inflammatory response, myocardial oxygen demand, microvascular coronary dysfunction, vascular remodeling, claudication


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