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Current Vascular Pharmacology

Eiditor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Decreasing Arterial Aging by Controlling Blood Pressure Levels and Hypertension: A Step Forward

Author(s): Angelo Scuteri and Pedro Guimaraes Cunha

Volume 10 , Issue 6 , 2012

Page: [702 - 704] Pages: 3

DOI: 10.2174/157016112803520954

Price: $58

Abstract

Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia.

Keywords: Arterial aging, pulse wave velocity, hypertension treatment, hypotension, cognitive impairment


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