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Current Cardiology Reviews

Eiditor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Treating and Preventing No Reflow in the Cardiac Catheterization Laboratory

Author(s): Ryan Berg and Cyrus Buhari

Volume 8 , Issue 3 , 2012

Page: [209 - 214] Pages: 6

DOI: 10.2174/157340312803217148

Price: $58

Abstract

The no reflow phenomenon can happen during elective or primary percutaneous coronary intervention. This phenomenon is thought to be a complex process involving multiple factors that eventually lead to microvascular obstruction and endothelial disruption. Key pathogenic components include distal atherothrombotic embolization, ischemic injury, reperfusion injury, and susceptibility of coronary microcirculation to injury. Thus, pharmacologic and mechanical strategies to prevent and treat no reflow target these mechanisms. Specifically, pharmacologic therapy consisting of vasodilators and antiplatelet agents have shown benefit in the treatment of no-reflow and mechanical therapies such as distal protection and aspiration thrombectomy have also shown benefit.

Keywords: No-reflow, adenosine, verapamil, nitroprusside, aspiration thrombectomy, distal protection


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