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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Toxicokinetic Interaction Between Quetiapine and Antiretroviral Therapy Following Quetiapine Overdose

Author(s): P. Hantson, V. Di Fazio and P. Wallemacq

Volume 4 , Issue 1 , 2010

Page: [7 - 8] Pages: 2

DOI: 10.2174/187231210790980426

Price: $58


A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.

Keywords: Quetiapine, overdose, half life, antiretroviral therapy, CYP3A4

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