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Endocrine, Metabolic & Immune Disorders - Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

The Cannabinoid 2 Receptor as a Potential Therapeutic Target for Sepsis

Author(s): Kevin Richard Kasten, Johannes Tschop, Matthias Hans Tschop and Charles Curtis Caldwell

Volume 10 , Issue 3 , 2010

Page: [224 - 234] Pages: 11

DOI: 10.2174/187153010791936874

Price: $58

Abstract

The sepsis syndrome represents an improper immune response to pathogens and is associated with an unacceptably high rate of mortality. Although supportive care is of benefit to the septic patient, there are no viable therapeutics available that target the immune system suitable for the whole septic population. Recently, using a physiologically relevant murine mouse model, the cannabiniod 2 receptor has been shown to play a critical role in the host response to sepsis. Here, the structure, expression, signaling, and function of the CB2 receptor on leukocytes will be reviewed. Further, the effects mediated by the CB2 receptor during sepsis will be reviewed. Altogether, alterations in inflammation and the host response during sepsis by the CB2 receptor support its use as a possible therapeutic agent.

Keywords: Neutophils, macrophages, T cells, B cells, inflammation


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