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Central Nervous System Agents in Medicinal Chemistry

Eiditor-in-Chief

ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Bio Molecular Considerations in Major Depression and Ischemic Cardiovascular Disease

Author(s): Massimo Cocchi and Lucio Tonello

Volume 10 , Issue 2 , 2010

Page: [97 - 107] Pages: 11

DOI: 10.2174/187152410791196378

Price: $58

Abstract

In our study we have evaluated the theme of the platelet fatty acid composition in subjects with a clinical diagnosis of Major Depression (MD), in subjects with a clinical diagnosis of Ischemic Heart Disease (IHD) according to the coronary angiography and in control subjects. We have analyzed all the groups without taking in account therapies, gender and age. As far as we know, the platelet fatty acid composition has never been analyzed before, in MD. The results obtained with the Self Organizing Map (SOM) show the evidence of three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA), and Palmitic Acid (PA) in a peculiar position with respect to the biochemical characterization of MD and three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA) and Oleic Acid (OA) in a peculiar position with respect to the biochemical characterization of the IHD. Bio molecular considerations are made about the possibility of controlling positive changes in platelet viscosity, in both pathologies.

Keywords: Consciousness, fatty acids, gamma synchrony, ischemic heart disease, major depression, platelets, self organizing map, stem cell


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