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Infectious Disorders - Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Antibiotic Treatment in Native Valve Infective Endocarditis

Author(s): Rafael Garcia-Borbolla and Mariano Garcia-Borbolla

Volume 10 , Issue 1 , 2010

Page: [47 - 58] Pages: 12

DOI: 10.2174/187152610790410927

Price: $58

Abstract

Previous to the availability of antimicrobial therapy, infective endocarditis (IE) was habitually lethal. Although approximately 80 percent of patients with endocarditis currently survive their infections, one of every six patients with IE does not survive the initial hospitalization, and up to one-third of patients infected with highly virulent organisms (such as Staphylococcus aureus) may die as a direct or indirect result of their valvular infection. An unfavourable outcome in these patients can occur despite having received appropriate antimicrobial therapy in a suitable approach, and despite the expert use of modern diagnostic techniques. Our purpose is to review the main issues related to the antimicrobial therapy.

Keywords: Infective endocarditis, microorganisms, antimicrobial regimens


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