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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Soluble Epoxide Hydrolase, a Target with Multiple Opportunities for Cardiovascular Drug Discovery

Author(s): Joseph P. Marino Jr.

Volume 9 , Issue 5 , 2009

Page: [452 - 463] Pages: 12

DOI: 10.2174/156802609788340805

Price: $58


Soluble epoxide hydrolase (sEH) is a cross-functional target, with the potential for therapeutic utility in the areas of hypertension, inflammation, and organ-protection [1]. Promising target validation has emerged around soluble epoxide hydrolase in recent years which suggests that small molecule inhibitors may have utility in cardio protection, glucose regulation, hypertension, inflammation, and organ protection. Based on the diversity of chemical classes of sEH inhibitors reported in the literature, there exists a real opportunity to definitively determine the best therapeutic utility for an sEH inhibitor. Recent advances in target validation and tool compounds from medicinal chemistry efforts will be described.

Keywords: Soluble epoxide hydrolase, epoxyeicosatrienoic acids, EETs, dihydroxyeicosatrienoic acids, DHETs, P450 monooxygenase, Ephx2

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