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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB

Author(s): R. M. Riggs, R. K. Jennings, E. R. Derstine, T. M. Nguyen, T. Trinh and J. M. Riordan

Volume 5 , Issue 1 , 2008

Page: [25 - 28] Pages: 4

DOI: 10.2174/157018008783406615

Price: $58


Multi-drug resistant tuberculosis is a worldwide problem where despite treatment; mortality can range up to 18%. An N-aryl 2-aminothiazole-4-carboxamide derivative was identified as a lead compound in a Tuberculosis Coordinating Antimicrobial Acquisition Facility (TCAAF) screen. Synthesis and biological evaluation of additional analogs led to structure-activity relationships for activity against TB.

Keywords: Tuberculosis, Antimycobacterial, Structure-activity relationships

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