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Mini-Reviews in Medicinal Chemistry

Eiditor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

New Approaches to Raising the HDL Cholesterol Level

Author(s): Hisashi Shinkai

Volume 2 , Issue 3 , 2002

Page: [271 - 276] Pages: 6

DOI: 10.2174/1389557023406115

Price: $58

Abstract

Not only a high level of low-density lipoprotein (LDL) cholesterol, but also a low level of highdensity lipoprotein (HDL) cholesterol, is a critical risk factor for atherosclerosis and coronary heart disease. Although fibrates and niacin can be used to improve low HDL cholesterol levels, their effect is not wholly satisfactory, so better drugs for the elevation of HDL cholesterol are desired. Among the many methods that may be used to raise HDL cholesterol levels, this review focuses on inhibitors of cholesteryl ester transfer protein (CETP) and on nuclear orphan receptor agonists that mediate the expression of ATP-binding cassette transporter 1 (ABC1).

Keywords: hdl, hdl cholesterol, cetp inhibitor, abc1


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