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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application

Author(s): Yasuyuki Shimada and Fumio Yamamoto

Volume 4 , Issue 1 , 2007

Page: [9 - 14] Pages: 6

DOI: 10.2174/157018007778992838

Price: $58


The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.

Keywords: Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide

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