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Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Endothelial Progenitor Cells in Prehypertension

Author(s): Rossella Di Stefano, Maria Chiara Barsotti, Francesca Felice, Charalambos Vlachopoulos and Alberto Balbarini

Volume 17 , Issue 28 , 2011

Page: [3002 - 3019] Pages: 18

DOI: 10.2174/138161211798157775

Price: $58

Abstract

Blood pressure within prehypertensive levels confers higher cardiovascular risk. As prehypertension is also an intermediate stage for full hypertension, a precocious intervention with lifestyle changes or drugs is therefore appealing. Endothelial injury and dysfunction are thought to contribute to cardiovascular risk in prehypertension. Endothelial progenitor cell impairment has been linked to endothelial dysfunction, atherosclerotic disease progression and cardiovascular events. A potential mechanism contributing to the heightened cardiovascular risk in prehypertension may be linked to abnormalities in endothelial progenitor cell number and/or function.

Aim of this review is to be up to date about the recent work on the correlation between endothelial progenitor cells and prehypertension and the possible prevention, treatment, and control of this pathology. The effect of an approach based on dietary intervention on both blood pressure and endothelial progenitor cells will be also shown.

Keywords: Prehypertension, hypertension, endothelial progenitor cells, cardiovascular system, drug therapy, nutrition, diabetes mellitus, obesity, chemokines, oxidative stress


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