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Current Drug Targets

Eiditor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Triple Threat: The Na+/Ca2+ Exchanger in the Pathophysiology of Cardiac Arrhythmia, Ischemia and Heart Failure

Author(s): Christian Pott, Lars Eckardt and Joshua I. Goldhaber

Volume 12 , Issue 5 , 2011

Page: [737 - 747] Pages: 11

DOI: 10.2174/138945011795378559

Price: $58

Abstract

The Na+/Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism of the cardiac myocyte and thus is crucial for maintaining Ca2+ homeostasis. It is involved in the regulation of several parameters of cardiac excitation contraction coupling, such as cytosolic Ca2+ concentration, repolarization and contractility. Increased NCX activity has been identified as a mechanism promoting heart failure, cardiac ischemia and arrhythmia. Transgenic mice as well as pharmacological interventions have been used to support the idea of using NCX inhibition as a future pharmacological strategy to treat cardiovascular disease.

Keywords: Na+/Ca2+ exchanger, arrhythmia, ischemia, heart failure, transgenic mice, Ca2+ handling, NCX, genetic knockout, hypertension, cardiovascular disease


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