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Current Vascular Pharmacology

Eiditor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Review Article

Managing Clopidogrel Hypersensitivity without Interrupting Therapy: The Toronto Approach

Author(s): Asim N. Cheema*

Volume 17 , Issue 2 , 2019

Page: [119 - 122] Pages: 4

DOI: 10.2174/1389200219666180820114435

Price: $58

Abstract

Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous manifestations in most patients to angioedema in some and a systemic immune response in rare cases. The treatment options include drug discontinuation with or without desensitization therapy, switching to alternate ADP receptor antagonists or administration of oral steroids while continuing clopidogrel in patients at high risk of adverse events with clopidogrel discontinuation. In this review the author describes the phenomenon of clopidogrel hypersensitivity, various treatment strategies.

Keywords: Clopidogrel, hypersensitivity, ADP receptor antagonist, drug allergy, adverse drug reaction, skin rash.

Graphical Abstract
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