Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?

Title:Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?

Volume: 14 Issue: 2

Author(s): Djordje Radak, Slobodan Tanaskovic, Niki Katsiki and Esma R. Isenovic

Affiliation:

• Institute Vinca, Laboratory of Radiobiology and Molecular Genetics, University of Belgrade, P.O. Box 522, Belgrade, Serbia.,0

Keywords: Diabetes mellitus, abdominal aortic aneurysm, atherosclerosis, risk factors.

Abstract: An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.