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CNS & Neurological Disorders - Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Drainage of Cerebral Abscesses Prior to Valve Replacement in Stable Patients with Acute Left-Sided Infective Endocarditis

Author(s): Adrian Molnar, Ruxandra Beyer, Stefan Florian, Dafin F. Muresanu, Catalin Trifan, Ioan Muresan, Diana Sacui, Traian Scridon and Radu N. Balanescu

Volume 14 , Issue 4 , 2015

Page: [534 - 539] Pages: 6

DOI: 10.2174/1871527314666150317224921

Price: $58

Abstract

Despite the medical and surgical advancements in the treatment of patients with acute infective endocarditis (IE), neurologic complications remain problematic. They can arise through various mechanisms consisting of stroke or transient ischemic attack, cerebral hemorrhage, mycotic aneurysm, meningitis, cerebral abscess, or encephalopathy. Most complications occur early during the course of IE and are characteristic to left-sided pathology of native or prosthetic valves. We present a case of a 46 year old male patient who presented to our clinic with mitral valve IE caused by coagulase negative staphylococcus. Although under correct antibiotic treatment, he continued to be feverish and started to present unspecific neurological symptoms (amnesia, confusion, asthenia and general malaise). The cerebral magnetic resonance imaging (MRI) revealed multiple cerebral abscesses. Because the patient was hemodynamically stable we decided to address the cerebral abscess first and the cardiac lesion second. The patient made a full recovery after undergoing antibiotic treatment and surgical procedures of drainage of the cerebral abscess and mitral valve replacement. After reviewing the literature regarding the management of patients with IE and cerebral complications and based on this particular case, we conclude that in select cases of stable patients with cerebral abscess and IE, the neurological lesion should always be addressed first and cardiac surgery should be performed second.

Keywords: Cardiac surgery, cerebral abscess, endocarditis, neurological complications, neurosurgery, valve replacement.


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