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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Eiditor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

The Effect of the Antioxidant Drug "U-74389G" on Oophoritis During Ischemia Reperfusion Injury in Rats

Author(s): Constantinos Τsompos, Constantinos Panoulis, Konstantinos Τοutouzas, George Ζografos and Apostolos Papalois

Volume 13 , Issue 2 , 2014

Page: [103 - 107] Pages: 5

DOI: 10.2174/1871523013666140804230111

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Abstract

The aim of this experiment was to study the effects of the antioxidant drug “U-74389G” on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean oophoritis (OI) lesions. Materials and methods: 40 rats were used of mean weight 231.875 g. OI was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B were without the drug but C and D with U-74389G administration. Results were that U-74389G administration kept non-significantly increased the OI scores by 0.05±0.051 without lesions (p=0.3204). Reperfusion time kept non-significantly increased the OI scores by 0.05±0.051 also without lesions (p=0.3204). Nevertheless, U-74389G administration and reperfusion time together kept non-significantly increased the OI scores by 0.045±0.030 (p=0.1334). Conclusions: Results of this study indicate that U-74389G administration, reperfusion time and their interaction declined the increased OI scores from significant to non-significant level.

Keywords: Oophoritis, reperfusion, U-74389G.

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