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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Use of Dexmedetomidine in Anesthesia and Intensive Care: A Review

Author(s): Ehab Farag, Maged Argalious, Alaa Abd-Elsayed, Zeyd Ebrahim and D. John Doyle

Volume 18 , Issue 38 , 2012

Page: [6257 - 6265] Pages: 9

DOI: 10.2174/138161212803832272

Price: $58


The alpha-2 agonist dexmedetomidine is being increasingly used for sedation and as an adjunctive agent during general and regional anesthesia. It is used in a number of procedures and clinical settings including neuroanesthesia, vascular surgery, gastrointestinal endoscopy, fiberoptic intubation, and pediatric anesthesia. The drug is also considered a nearly ideal sedative agent in the intensive care setting. However, the drug frequently produces hypotension and bradycardia, and also decreases cerebral blood flow without concomitantly decreasing the cerebral metabolic rate for oxygen. This review discusses recent advances in the use of dexmedetomidine in anesthesia and intensive care settings, as well as discuss potential problems with its use.

Keywords: Anesthesia, dexmedetomidine, surgery

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