Generic placeholder image

Current Drug Targets

Eiditor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Prevention of Intracerebral Haemorrhage

Author(s): Patrick Mitchell, Dipayan Mitra, Barbara A. Gregson and A. David Mendelow

Volume 8 , Issue 7 , 2007

Page: [832 - 838] Pages: 7

DOI: 10.2174/138945007781077328

Price: $58

Abstract

Nontraumatic intracerebral haemorrhages arise from a wide range of causes falling into two broad groups: discreet vascular “ictohaemorrhagic” lesions such as aneurysms, arteriovenous malformations, cavernomas, tumours, and dural fistulae; and more generalised amyloid or hypertension related conditions. It is now possible using family history, associated risk factors and gradient echo MRI to predict cases at high risk of hypertensive or amyloid related haemorrhage. There is considerable potential for prevention of hypertensive haemorrhages by treatment of high risk cases with antihypertensive medication. As yet no effective preventative treatment for amyloid angiopathy related ICH has emerged although a variety of drugs are under investigation. Prevention of haemorrhage from ictohaemorrhagic lesions revolves around removal or obliteration of the lesion. Although there is a wide range of such lesions available treatments come down to three modalities. These are surgical excision, stereotactic radiosurgery and endovascular embolisation.

Keywords: ictohaemorrhagic lesion, antithrombotic, embolisation, Arteriovenous malformations, Aneurysms


Rights & Permissions Print Export Cite as
Article Metrics
3
Related Journals
Related eBooks