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Current HIV Research

Eiditor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

HIV-1 Infection in Subjects Older than 70: A Multicenter Cross-Sectional Assessment in Catalonia, Spain

Author(s): Beatriz Mothe, Inaki Perez, Pere Domingo, Daniel Podzamczer, Esteban Ribera, Adrian Curran, Consuelo Vilades, Francesc Vidal, David Dalmau, Enrique Pedrol, Eugenia Negredo, Jose Molto, Roger Paredes, Nuria Perez-Alvarez, Jose Maria Gatell and Bonaventura Clotet

Volume 7 , Issue 6 , 2009

Page: [597 - 600] Pages: 4

DOI: 10.2174/157016209789973691

Price: $58

Abstract

We designed a multicenter cross-sectional study to describe the epidemiological characteristics of the HIV-1- infected population aged 70 years or more in our setting. 179 individuals from eight university hospitals in Barcelona, Spain, were included, representing 1.5% of HIV-1 infected subjects followed during 2008. Most subjects were male (76%) and had acquired HIV infection through sexual intercourse (87%); 69% had been diagnosed with HIV-1 after their sixties. The CD4 cell counts at HIV-1 diagnosis were < 200 cells/mm3 in 52% of individuals, whereas this was only seen in 34% of subjects from a published cohort including younger HIV- infected adults from the same setting [1]. Most of our patients were on HAART, had undetectable HIV-1 viremia and the most recent median CD4 cell counts were 350 cells/mm3. 154 subjects had at least one comorbid condition, including dyslipidemia (54%), hypertension (36%), hyperglicemia or diabetes (30%), cardiovascular disease (23%), chronic renal failure (18%), history of neoplasia (17%) and cognitive impairment (11%). Lipodystrophy was reported in 58% of individuals. Rates of hypercholesterolemia, diabetes and cancer were higher than those reported in unselected local population (28%, 17% and 7%, respectively). The study participants were taking an average of 2.97 drugs (range 1-10) other than antiretrovirals. In conclusion, the elder population infected with HIV-1 is likely being diagnosed late and at lower CD4+ counts and is frequently affected by comorbidities and co-medication. Based on our findings, we suggest some recommendations regarding the management of this growing population.

Keywords: Aging, HIV/AIDS, comorbidity, polypharmacy, geriatric assessment


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