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Current HIV Research

Eiditor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Cerebrovascular Diseases in HIV-Infected Patients

Author(s): Jean-Jacques Monsuez, Colette Goujon, Benjamin Wyplosz, Carine Couzigou, Lelia Escaut and Daniel Vittecoq

Volume 7 , Issue 5 , 2009

Page: [475 - 480] Pages: 6

DOI: 10.2174/157016209789346345

Price: $58

Abstract

Cerebrovascular disease (CVD) has early been recognized in HIV-infected patients, including infectious arteritis, inflammatory vasculitis, aneurismal and small-vessel arteriopathy, to which adds now the premature atherosclerotic cerebral arteriopathy associated with the highly active antiretroviral therapy (HAART)-induced metabolic disorders. As a result of the increased life-expectancy associated with HAART, HIV patients grow older and are exposed to the combined vascular risk of antiviral-induced metabolic changes and advancing age. Several studies have documented subclinical cervical artery atherosclerosis, as assessed by intima-media thickness, ultrasound detection of carotid artery plaques and intracerebral small-vessel disease, all being associated with the induced metabolic changes. This suggests that vascular prevention should be performed on a long-term basis.

Keywords: HIV, AIDS, Stroke, Cerebrovascular disease


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