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Current Drug Targets - Inflammation & Allergy

Eiditor-in-Chief

ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

MEFV Mutation Carriers and Diseases Other than Familial Mediterranean Fever: Proved and Non-Proved Associations; Putative Biological Advantage

Author(s): Daniel Cattan

Volume 4 , Issue 1 , 2005

Page: [105 - 112] Pages: 8

DOI: 10.2174/1568010053622948

Price: $58

Abstract

Vasculitis is definitely associated with familial Mediterranean fever. This familial Mediterranean fever-associated vasculitis takes one of three forms: polyarteritis nodosa, with or without microscopic polyangiitis, and Henoch-Schonlein purpura. Behcet disease and inflammatory bowel diseases may also be associated with familial Mediterranean fever, though this is yet to be formally proven. The selective biological advantage, if any, for carriers of simple heterozygotic mutations in the gene responsible for familial Mediterranean fever, MEFV, is not known. Indirect arguments are given for a better defense against certain groups of bacterial pathogens and amongst intra-cellular bacteria, Mycobacterium tuberculosis.

Keywords: familial mediterranean fever, mefv gene, vasculitis, behcet disease, Inflammatory bowel diseases, selective advantage, jews, tunis, tuberculosis


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