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Cardiovascular & Hematological Disorders-Drug Targets

Eiditor-in-Chief

ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

A Case of Ischemic Stroke in Acute Promyelocytic Leukemia at Initial Presentation: Relevance of All-Trans Retinoic Acid Treatment

Author(s): Angelo M. Carella, Giuseppe Antonucci, Matteo Conte, Michele Di Pumpo, Elisabetta Antonucci and Ernestina Ponziano

Volume 10 , Issue 1 , 2010

Page: [1 - 6] Pages: 6

DOI: 10.2174/187152910790780069

Price: $58

Abstract

Acute promyelocytic leukemia (APL) is frequently associated, often from the earliest phases, with a lifethreatening coagulation/bleeding syndrome; disseminated intravascular coagulation (DIC) is described in majority of patients. We report a case of 49-year-old male, without cardiovascular risk factors, who suddenly developed ischemic stroke and splenic infarction as presenting symptoms of APL and related DIC. The patient was immediately treated with all-trans retinoic acid (ATRA) and the alterations of hemocoagulation parameters promptly returned in normal range. The coagulation/ bleeding syndrome of the onset of APL is associated with high mortality; both diagnostic and therapeutic approaches require special and timely consideration of this condition. Treatment with ATRA is essential.

Keywords: Acute promyelocytic leukemia, Disseminated intravascular coagulation, Ischemic stroke, All-trans retinoic acid


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