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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

The Association of Connective Tissue Disorders with Cervical Artery Dissections

Author(s): Caspar Grond-Ginsbach and Stephanie Debette

Volume 9 , Issue 2 , 2009

Page: [210 - 214] Pages: 5

DOI: 10.2174/156652409787581547

Price: $58


A predisposing weakness of the vessel wall has been assumed in patients with spontaneous cervical artery dissections (sCAD). Skin biopsies from many patients with sCAD show mild connective tissue alterations. However, their assessment depends on an invasive and highly specialized technique. Clinical signs of connective tissue disease are absent in the majority of CAD patients. In this review we document that only very few CAD patients are affected by known inherited connective tissue disorders like Ehlers-Danlos syndrome, Marfan syndrome or Osteogenesis Imperfecta. In a second part of this review we discuss the possible role of unrecognized or unknown forms of connective tissue disorders in the etiology of CAD.

Keywords: Connective Tissue, spontaneous cervical artery dissections (sCAD), Osteogenesis, Ehlers-Danlos syndrome, etiology

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