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Current Pharmaceutical Design

Eiditor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Cardiac Metabolism in Diabetes Mellitus

Author(s): Michihiro Yoshimura, Ryuko Anzawa and Seibu Mochizuki

Volume 14 , Issue 25 , 2008

Page: [2521 - 2526] Pages: 6

DOI: 10.2174/138161208786071263

Price: $58

Abstract

Diabetes mellitus is one of the most common chronic illnesses throughout the world. Diabetic cardiomyopathy is a specific syndrome, consisting of cardiomegaly, left ventricular dysfunction, electrical remodeling of the ventricle, and symptoms of congestive heart failure, that is seen in diabetic patients in the absence of other predisposing factors. Many researchers have suggested that inhibition of the renin-angiotensin-aldosterone system and the sympathetic nervous system may exert a therapeutic effect in individuals with diabetic cardiomyopathy. Indeed, angiotensin II and aldosterone blockade may be effective, partly because aldosterone blockade down-regulates Na+/H+ exchanger 1 activity. Further study of the alterations in ion channel physiology in the context of diabetic cardiomyocytes may be of benefit.

Keywords: Diabetes, cardiomyopathy, metabolism, renin-angiotensin-aldosterone system, hyperglygemia, hyperinsulinemia


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